scdrs.method.downstream_corr_analysis#
- scdrs.method.downstream_corr_analysis(adata: AnnData, df_full_score: DataFrame, var_cols: List[str]) DataFrame[source]#
scDRS cell-level correlation analysis.
For a given individual cell-level annotation (e.g., T cell effectorness gradient), assess association between disease and the individual cell-level variable (control-score-based Monte Carlo tests using Pearson’s correlation).
- Parameters:
- adataanndata.AnnData
Single-cell data of shape (n_cell, n_gene). Assumed to be size-factor-normalized and log1p-transformed.
- df_full_scorepd.DataFrame
scDRS .full_score file for a given trait.
- var_colsList[str]
List of column names in adata.obs for continous cell-level variables.
- Returns:
- df_respd.DataFrame
Correlation results (n_var, n_stats).